Preheat oven to 425 degrees. Prepare a rimmed baking sheet with parchment paper, lightly sprayed with cooking spray.
Place the 2 tablespoons of flour in a gallon-sized plastic bag. Set aside.
In a long shallow dish, beat the egg and add the garlic, onion, salt, and black pepper. Mix again, incorporating all the spices evenly. Set aside.
In a separate long shallow dish, add the Panko crumbs and grated cheese. Mix to combine.
Set up the breading station with the bag of flour first, seasoned beaten egg, and last the Panko and cheese.
Place the trimmed and dried asparagus spears, 4 at a time, in the bag with the flour. Shake until the spears are coated with flour. (See Notes) Removing one spear at a time, roll in seasoned egg mixture. Let excess egg drip off, but don’t shake off.
Roll in panko crumbs to completely cover and place on the prepared pan. Repeat until all the spears are coated. Spears should not touch each other.
Lightly spray with cooking spray. This will help the crumbs become crisp.
Bake for 15-20 minutes, or until golden brown. Don’t overcook. Serve warm.